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中南大学湘雅医院皮肤科团队连续发表黑素瘤发病及治疗机制研究成果

来源:湖南快乐十分_湖南快乐十分钟_【官网推荐】

本网讯 中南大学湘雅医院皮肤科、皮肤肿瘤与银屑病湖南省重点实验室、中南大学皮肤健康与疾病湖南省工程研究中心团队,最近连续在自然子刊《自然通讯》以及皮肤科专业顶尖学术期刊Journal of Investigative Dermatology、国际知名肿瘤学期刊Oncogene上发表研究论文,揭示新型抑制剂治疗黑素瘤有效的核心机制、黑素瘤发病的新机制及性别相关分子差异在皮肤黑素瘤免疫治疗中的作用,为治疗黑素瘤提供了新策略。团队自主研发的新药即将进入以黑素瘤为主要适应症的临床I期试验,有望成为广谱抗癌新药。

揭示新型抑制剂治疗黑素瘤有效的核心机制,开发原创抗癌新药

4月14日,中南大学湘雅医院皮肤科、中南大学皮肤健康与疾病湖南省工程研究中心皮肤疾病临床转化团队在《自然通讯》(Nature Communication湖南快乐十分,IF:11.878)发表题为“Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction”的研究论文。该研究第一作者和共同通讯作者单位均为湘雅医院皮肤科,印明柱教授为第一作者,陈翔教授、印明柱教授及耶鲁大学严钦教授为共同通讯作者。

湖南快乐十分gaiyanjiushoucijieshilezizhuyanfadexinxingbetyizhijinhwd-870tongguozuduanzhongliu-jushixibaohuzuojizhi,weilinchuangzuduanbiaoguanyichuanxinbadianbrd4youxiaozhiliaoheisuliuweidaibiaodeshitiliutigonglelilunyiju。yanjiufaxian,gaiyizhijijiaotongleihuahewulinchuanghuoxingtishengle5-50bei,qiekeyouxiaonizhuanzhongliudenaiyaoxing,youwangjiangwanqiheisuliuhuanzhedeshengcunshijiantigaoyibei。zuoweiyuningbowendayiyaokejiyouxiangongsihezuokaifade1.1leiyuanchuangxinyao,nhwd-870jiangyujinnian7yueyouxiangyayiyuanpifukechenxiangjiaoshouzuoweizhupi,lvxiankaizhanyiheisuliuweizhuyaoshiyingzhenglinchuangiqishiyan,youwangchengweiguangpukangaixinyao,weiwanqiheisuliu、xiaoxibaofeiaidenghuanzhedailailexindezhiliaoxiwang。

湖南快乐十分pifuheisuliushiyouheisesuxibaoyichangzengzhisuodaozhideexingzhongliu,juyouqinxiliqiang、yizhuanyi、yifufadengtedian,jupifuzhongliuzhisiyuanyindeshouwei。zaihunankuaileshifenguo,zuiduojiandepifuheisuliulinchuangleixingweizhiduanxingjinianmoxing,qieyimeinian3-5%defabingsulvkuaisuzengzhang。zaoqiheisuliushoushuxiaoguojiaohao,dan60-70%weiwanqipifuheisuliuhuanzhe,5nianshengcunlvjinwei5%,exingchengdujigao,muqianfuzhuxingganraosu、changguihualiaodengzhiliaoshouduanliaoxiaoqianjia。

“dangbufenwanqiaizhenghuanzheyijing‘wuyaokeyong’shi,hunankuaileshifenxindebaxiangyaowuhuijitamendailaixindexiwang,keyiyanhuanmouxieaizhengdeehuashenzhizhiyu。”yinmingzhujiaoshoubiaoshi。zheiyiqiedoudeyiyulinchuangzhuanhuatuanduifaxiandeyizhongxinxingbetyizhijinhwd-870,gaiyizhijijiaotongleihuahewulinchuanghuoxingtishengle5-50bei,keyihenrongyidaodashitiliudeweizhi,yincihendidenongdujiukeyidadaolianghaozhiliaoxiaoguo。

湖南快乐十分gaiyanjiudelingyidachuangxinzaiyu,jieshilenhwd-870diaokongzhongliumianyiweihuanjingdequanxinjizhi。yanjiuxianshiheisuliuzuzhizhongdedaliangjushixibaozishenbiaodapdl-1danbaigaoyuzhongliubiaodajin50bei,shidaozhipd1/pdl1kangtizhiliaowuxiao/naiyaozhuyaoyuanyinzhiyi,muqianheisuliuyixianzhiliaobaxiangyaowubrafyizhijihemekyizhijizaishiyong3-6geyuehuidaozhidabufenhuanzhechuxiannaiyao。ernhwd-870tongguozuduanzhongliu-jushixibaohuzuojizhi,conger“shasi”jushixibao,shizhongliubuyinaiyaohuoshenzhikenizhuannaiyaodegongxiao。yinci,gaiyizhijiyupd-1/pdl-1kangtihuoqitabaxiangyaowulianheshiyonghuiqidaogenghaodeliaoxiao。“wanqiheisuliudepingjunshengcunqishi6geyuezuoyou,conghunankuaileshifendelinchuangqiandongwushiyanlaikan,shengcunqikenenghuiyanzhangyibei,youwangchaoguoyinian。”yinmingzhujiaoshoubiaoshi。

jiyugaohuoxinghenizhuannaiyaodetedian,nhwd-870youwangchengweiguangpukangaiyao。gaiyanjiushiyongle9gebutongzhongleidezhongliumoxing,faxianduiyuheisuliu、luanchaoai、ruxianai、feixiaoxibaofeiaidengshitiliujunyouxiaoguo。

揭示黑素瘤发病新机制,为治疗提供新策略

近日,中南大学湘雅医院皮肤科、皮肤肿瘤与银屑病湖南省重点实验室、皮肤健康与疾病湖南省工程研究中心陈翔教授、彭聪教授团队在皮肤科专业顶尖学术期刊Journal of Investigative Dermatology和国际知名肿瘤学期刊Oncogene上连续发表2篇研究论文,揭示了黑素瘤发病的新机制。

Journal of Investigative Dermatology上发表的“TRAF6 activates fibroblasts to cancer-associated fibroblasts (CAFs) through FGF19 in tumor microenvironment to benefit the malignant phenotype of melanoma cells”研究论文作者是博士研究生郭也也和张旭博士后,他们为并列第一作者;Oncogene 上发表的“The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis”研究论文作者是张旭博士后和黄遵楠教授,他们为并列第一作者;陈翔教授及彭聪教授为两篇论文的共同通讯作者,中南大学湘雅医院皮肤科为第一通讯单位。

gaituanduiweiraozhongliuweihuanjingyuheisuliu,shoucizhengmingletraf6zaiheisuliuzhongliuweihuanjingzhongdezhongyaozuoyong,goutongguonf-κbxinhaotonglucujinfgf19fenmi,daozhiheisuliuhuanzhexuejiangzhongfgf19xianzhushenggao,bingyoudaozhongliuxiangguanchengxianweixibaodehuohua,cujinzhongliuxibaoshengzhangyuqinxizhuanyi,chanmingleheisuliufabingdexinjizhi。

湖南快乐十分cd147zaiheisuliudeqinxizhuanyi、nengliangdaixieheduoyaonaiyaozhongyouzhezhongyaodezuoyong,shichenxiangjiaoshoutuanduiershiduonianlaiyizhizhiliyuyanjiudeyigegaodutangjihuakuamodanbai,qitangjihuaxiushiyucd147chengshu、xibaomodingweidenggongnengmiqiexiangguan。jucicilunwenbaodao,tamenshoucifaxiancd147bujinnenggoubeitangjihuaxiushi,tongshihainenggoubeilinsuanhuaxiushi,bingqiezheiliangzhongxiushizhijiancunzai“cross-talk”。yizhicd147linsuanhuashuipingnenggouyingxiangcd147yutangjihuazhuanyimeignt-vdejiehe,congerjiangdicd147detangjihuashuiping,yingxiangheisuliuxibaodeqinxizhuanyi,jieshilecd147fanyihouxiushizaiheisuzhongdexinzuoyongjizhi。

揭示性别相关分子差异在皮肤黑素瘤免疫治疗中的作用,指导个体化诊疗

4月14日,自然子刊NatureCommunications湖南快乐十分在线发表了中南大学湘雅医院皮肤科刘洪教授与美国德州大学休斯顿健康科学中心韩冷教授合作的“Sex-associate dmolecular differences for cancer immunotherapy”(性别相关分子差异在皮肤黑素瘤免疫治疗中的作用)的研究论文(doi: 10.1038/s41467-020-15679-x)的第一作者是叶幼琼研究员,韩冷教授、刘洪教授为论文的共同通讯作者。

近年来,抗PD-1/PD-L1疗法被用于皮肤黑素瘤等多种癌症治疗,延长了部分患者的生命,但是该疗法对高达60%的患者无效,何种因素决定了抗PD-1/PD-L1疗法是否有效对该疗法在临床上的应用和推广至关重要。越来越多的研究发现,性别差异在自身免疫性疾病和感染的免疫反应占据了重要地位,但是性别差异是否影响抗PD-1/PD-L1疗效尚不清楚。学术界对这一问题的争议由来已久,发表在权威期刊Lancet Oncology JAMA Oncology 的两项研究得出了截然相反的结论。因此,解决这一关键问题将有助于明确性别相关因素在免疫治疗中的地位,指导免疫治疗的个体化临床用药。

tongguowajueleduogeheisuliudengmianyizhiliaolinchuangshujuji,gaiyanjiujieshilexingbiexiangguanmianyiyinsuduipifuheisuliudengaizhengkangpd-1/pd-l1yingdalvdeyingxiang,qiangdiaolezaiweilaidelinchuangshiyanzhongtigongzuxueshujuduilejiexingbieduimianyizhiliaoyingxiangdezhongyaoxing,weijiejueguanyunanxinghenvxingaizhenghuanzhemianyizhiliaoxiaoguodefenzichayizheiyiredianwentitigonglezuiquanmiandefangan,duiyupifuheisuliudengzhongliuhuanzhedegetihuazhenliaojuyoushenyuandezhidaoyi。

yanjiuzhong,tuanduitongguoshengwuxinxixuefangfafenxilekangpd-1/pd-l1zhiliaoliaoxiaodemianyixiangguanfenzi(rupbrm 1、brca 2、mianyijianchadiandengbiaodashuiping)zaibutongxingbiezhongdechayi,bingliyongaizhengjiyinzutupu(tcga)hekangpd-1/pd-l1linchuangyanjiudeduozuxueshuju,faxianbutongaizhengleixingdemianyitezhengcunzaixingbiechayi。liru,heisesuliuzhongdenanxingpianxiangjuyougaoshuipingdemianyifanyingxiangguantezheng(rugaoshuipingdezhongliutubianfuhe),erfeixiaoxibaofeiaizhongnvxingpianxiangjuyougaoshuipingdemianyifanyingxiangguantezheng(rugaoshuipingdemianyijianchadianbiaoda)。zheixiejieguozaiduogedulidekangpd-1/pd-l1mianyizhiliaolinchuangshiyanshujujizhongdedaoleyanzheng。benyanjiujiandingleduozhongxingbiexiangguanmianyiyinsuyingxiangmianyijianchadianyizhijiliaoxiaodeshengwubiaozhiwu,weizhongliumianyijianchadianliaoxiaodexingbiechayilaiyuantigonglefenzicengmiandezhengju。

湖南快乐十分juxi,xiangyayiyuanpifuketuanduizhangqizhiliyupifuexingzhongliu,tebieshiheisuliudejichuyanjiu、zhuanhuayanjiujilinchuangyanjiu,zaiyanjiulunwen、yixuedashujuyushengwuyangben、mdttuanduihunankuaileshifen、pifubingwangluoyiyuanjianlidengfangxianghuodezhuduochengguo。tuanduiqiantouzujianlezhonghuayixuehuipifuxingbingxuefenhuipifuzhongliuyanjiuzhongxinhezhongguoyishixiehuipifukeyishifenhuipifuzhongliuzhuanyeweiyuanhui,bingyu2019nianlianheguojidingjianxuezhechenglixiangyapifuheisuliuguojiyanjiulianmeng。


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